Researchers analysed electronic clinical data from nearly three million women in Utah, including almost 100,000 with an endometriosis diagnosis. Endometriosis was associated with a 46% higher risk of type 2 diabetes after adjustment for measured factors.

The scale of the dataset strengthens the signal that endometriosis may have metabolic as well as reproductive-health dimensions. Observational clinical data can still contain coding gaps, unmeasured confounding and access-related bias, so the study does not establish causation or a new screening rule.

Replication in more diverse populations, prospective studies, mechanisms linking inflammation and metabolism, and whether risk stratification improves outcomes without unnecessary testing.